Somatic Brain Mosaicism

"Rearrangements can often occur in normal CNS stem and progenitor cells, albeit with an assay that captures DSB translocations to “baits” and thus actually underestimates DSB frequency in these genes. The general finding is that these DSBs occur mainly in transcribed genes that are late replicating. As reported for lymphocyte translocations and deletions, there are more joining events to nearby DSBs within the same chromosome than to distant loci."

https://www.sciencedirect.com/science/article/pii/S0092867415017031